Optimized bio-nano interface using peptide modified colloidal gold nanoparticles

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The interactions of synthetically produced colloidal gold nanoparticles (GNPs) with living organisms are gaining much attention in the biomedical sciences. While non-viral carriers, such as GNPs, are safer and more cost-efficient as compared to viral vectors, the probability of cell internalization is lower. In this paper, we discussed a method to increase cell internalization of GNPs using a specific peptide known as "RME-Peptide". Our results showed an enhancement in cell uptake of peptide-capped GNPs. Furthermore, we investigated the exocytosis process of peptide-capped GNPs. Our results showed that the peptide-modified GNPs had a lower number of NPs exocytosed as compared to citrate-capped or as-made colloidal GNPs. Our study shows that bio-nano interface can be improved using specially designed peptides on colloidal GNPs. The outcome of this research will be beneficial for their applications in therapeutics and imaging.




Yang, C., Yohan, D., & Chithrani, D. B. (2014). Optimized bio-nano interface using peptide modified colloidal gold nanoparticles. Colloids and Interface Science Communications, 1, 54–56. https://doi.org/10.1016/j.colcom.2014.07.003

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