Optimized bio-nano interface using peptide modified colloidal gold nanoparticles

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Abstract

The interactions of synthetically produced colloidal gold nanoparticles (GNPs) with living organisms are gaining much attention in the biomedical sciences. While non-viral carriers, such as GNPs, are safer and more cost-efficient as compared to viral vectors, the probability of cell internalization is lower. In this paper, we discussed a method to increase cell internalization of GNPs using a specific peptide known as "RME-Peptide". Our results showed an enhancement in cell uptake of peptide-capped GNPs. Furthermore, we investigated the exocytosis process of peptide-capped GNPs. Our results showed that the peptide-modified GNPs had a lower number of NPs exocytosed as compared to citrate-capped or as-made colloidal GNPs. Our study shows that bio-nano interface can be improved using specially designed peptides on colloidal GNPs. The outcome of this research will be beneficial for their applications in therapeutics and imaging.

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Yang, C., Yohan, D., & Chithrani, D. B. (2014). Optimized bio-nano interface using peptide modified colloidal gold nanoparticles. Colloids and Interface Science Communications, 1, 54–56. https://doi.org/10.1016/j.colcom.2014.07.003

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