Direct catalytic modifications of carbon–hydrogen (C–H) bonds, ubiquitous in organic molecules, represent a powerful strategy in organic synthesis. In the past decade, chemists have focused on the development of sustainable methods for functionalization of inert C–H bonds using cost-effective earth-abundant 3d transition-metal catalysts. To fully harness the potential of this technology, however, it is essential to control the stereoselectivity of the C–H functionalization processes. This review describes developments in the emerging area of enantioselective functionalization of C–H bonds by 3d transition-metal catalysts proceeding via inner-sphere C–H activation.
Woźniak, Ł., & Cramer, N. (2019, August 1). Enantioselective C–H Bond Functionalizations by 3d Transition-Metal Catalysts. Trends in Chemistry. Cell Press. https://doi.org/10.1016/j.trechm.2019.03.013