Changes in the extracellular matrix of the clitoris caused by aging: A stereological and comparative study

Abstract

Introduction: The clitoris is partially responsible for sexual arousal. The integrity of the extracellular matrix is essential for clitoral erection. Sexual dysfunction is a phenomenon associated with age. Methods: The clitoris of cadavers of 20- to 80-year-old women was excised and histologically processed. Stereological analysis was performed to quantify the volumetric density of collagen, elastic fibers, and smooth muscle. Results: A significant increase in collagen and a decrease in smooth muscle and elastic fibers were observed in older women. Conclusions: In short, these changes caused by aging could contribute to female sexual dysfunction concerning clitoral orgasm.