Warfarin-induced intracerebral hemorrhage associated with microbleeds

Abstract

Background: Microbleeds (MBs), proposed as a biomarker for microangiopathy, have been suggested as a predictor of spontaneous or thrombolysis-related intracerebral hemorrhage (ICH) in acute ischemic stroke. However, the relationship between MBs and warfarin-induced ICH is not clear. Case Report: We describe two patients who developed warfarin-induced ICH at the site of MBs documented in previous MRI. Conclusions:: The presence of MBs might increase the risk of ICH after warfarin use in ischemic stroke patients. A large cohort study is required to confirm the relationship of MBs with warfarin-induced ICH. © 2008 Korean Neurological Association.