Effect of salam leaf extract (Syzygium polyanthum to decrease blood triglyceride white rats

Abstract

Nugroho AA, Hikmayanti NH, Djumaga S. 2012. Effect of salam (Syzygium polyanthum) leaf extract to decrease blood triglyceride level on white rats. Biofarmasi 10: 40-45. This study aimed to determine the effect of bay [Syzygium polyanthum (Wight) Walp.] leaf extract to decrease the blood triglyceride level of white rats (Rattus norvegicus). This research was an laboratory experimental research with pre and post-test design with control group. This research used 30 Wistar white rats, with ±200 g body weight and the age of ±2 months, divided into 5 groups by a random sampling, six rats per group. Group I was a negative control, group II was a positive control, groups III, IV and V was treated with the bay leaf extract in the doses of I, II and III. All groups were fed of hyperkolemia, group II was treated by Gemfibrozil 20 mg/200 g BW/day, while groups III, IV and V were treated by the bay leaf extract with the doses of 0.18 g, 0.36 g and 0.72 g/200 g BW/day. The study was conducted for 35 days. On the 28th and 35th day, the blood of all rats was taken from orbital vein for blood triglyceride levels measured in pre-test and post-test. The data were statistically analyzed with One-Way ANOVA test and a post-hoc test. There were significant differences between pre-test and post-test in the levels of blood triglycerides of white rats (p<0.001), in which a post-hoc test results showed the comparison between negative control and Gemfibrozil was p<0.001, and the comparison between the groups of the bay leaf extract with Gemfibrozil was p>0.05, and the comparison of three doses of bay leaf extract was p>0.05. The provision of bay leaf extract could reduce the blood triglyceride levels of white rats significantly compared with the negative control, whereas the effects of three doses of bay leaf extract was comparable with the effects of Gemfibrozil.