Polo-like kinase 1 (Plk1) regulates mitotic progression in all eukaryotes and has been implicated in the transformation of human cells. Analysis of the cytological and anti-tumor activities of BI 2536, a novel, selective pharmacological inhibitor of Plk1, has connected chemistry and biology to the bedside. © 2007 Elsevier Ltd. All rights reserved.
Plyte, S., & Musacchio, A. (2007, April 17). PLK1 Inhibitors: Setting the Mitotic Death Trap. Current Biology. https://doi.org/10.1016/j.cub.2007.02.018