Newly made mitochondrial DNA drives inflammation

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Abstract

Activation of the inflammasome protein complex in immune cells is a key step that triggers an innate immune response. It emerges that the synthesis and oxidation of mitochondrial DNA drives this activation step.

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Murphy, M. P. (2018). Newly made mitochondrial DNA drives inflammation. Nature, 560(7717), 176–177. https://doi.org/10.1038/d41586-018-05764-z

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