We studied the intrahepatic hepatitis B virus (HBV) replicative status in 40 people with occult hepatitis B infection (OBI) and 40 patients with chronic hepatitis B (CHB). Intrahepatic HBV DNA, covalently closed circular DNA (cccDNA), and pre-genomic RNA (pgRNA) were quantified. Patients with OBI had median necroinflammation and fibrosis scores of 1 and 0, respectively. Intrahepatic total HBV DNA, cccDNA and pgRNA were detectable in 30 (77%), one (3%) and five (13%) of the participants with OBI, respectively. People with OBI had lower median intrahepatic total HBV DNA than the patients with CHB (< 0.0001). They had nearly normal liver histology and low intrahepatic HBV replication.
Wong, D. K. H., Fung, J., Lee, C. K., Seto, W. K., Leung, J., Huang, F. Y., … Yuen, M. F. (2016). Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection. Clinical Microbiology and Infection, 22(3), 290.e1-290.e3. https://doi.org/10.1016/j.cmi.2015.10.036