Prevention of CAR-T-cell dysfunction

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Abstract

The overexpression of the transcription factor c-Jun improves chimeric-antigen-receptor T-cell functionality and enhances the killing of low-antigen-expressing liquid and solid cancers in mice.

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LaFleur, M. W., Miller, B. C., & Sharpe, A. H. (2020, January 1). Prevention of CAR-T-cell dysfunction. Nature Biomedical Engineering. Nature Research. https://doi.org/10.1038/s41551-019-0512-2

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