An approach to noninvasive delivery, biodistribution, and fertility control potential evaluation of the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide in the female

Abstract

Under guidance of an external pulsed magnetic field the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide delivered into the rat/rabbit oviduct resulted in oocytes with granulated cytoplasm, zona enlargement, membrane disintegration, and finally loss of viability in 72 hours. Also, the percentage biodistribution of magnetic and electrically conductive particles observed under safe level advocates the use of Cuproferrogel as a potential female fertility control molecule. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc.