Radioembolization of Hepatic Metastases with90Y-Microspheres: Indications and Procedure

Abstract

Radioembolization using 90Y-microspheres (90Y-RE) represents a safe and efficacy technique for treating metastatic liver malignancies with a growing number of ongoing trials and clinical experience in different types of tumors. 90Y-RE is treatment modality that needs to be adapted to the individual patient, every step of the way. The appropriate patient selection for selection of patients to the treatment requires a multidisciplinary discussion to provide a benefit with acceptable risk. Pre-therapy workup, therapy planning and intra-arterial infusion of 90Y-microspheres procedure require an experienced and synergic team formed by nuclear medicine physician, interventional radiologist and medical physicist. A personalized therapeutic plan with a tailored target volume and prescribed dose should be developed for each patient after analysis of all clinical, laboratory and multimodality imaging data. Both efficacy and safety will result improved as the patient’s selection will be more appropriate and delivery technique accurate.