Asymmetric Michael reaction promoted by new chiral phase-transfer catalysts

Abstract

A catalytic asymmetric Michael reaction promoted by new chiral quaternary ammonium salts is described. The products are obtained with moderate ee (up to 75% ee), and the enantioselectivity is strongly dependent on both the substituents on the aromatic rings and the ammonium moiety in the catalysts. © 2004 Pharmaceutical Society of Japan.