Three children with terminal cancer, ages 7, 9, and 14 years, who exhibited severe symptoms of depression and anxiety, were treated with a combination of low dose amitriptyline (1–2 mg/kg/24 hours) and haloperidol (0.05–0.10 mg/kg/24 hours). Anxiety decreased, mood improved, vegetative symptoms were alleviated, and requirements for narcotic analgesia decreased within 1 week of inception of pharmacotherapy. Symptoms reemerged in two patients when the medications were discontinued. Importantly, the psychopharmaco-logic interventions allowed the patients and their families to deal with the dynamic issues involved in chronic illness and death and dying. © 1985, The American Academy of Child Psychiatry. All rights reserved.
MAISAMI, M., SOHMER, B. H., & COYLE, J. T. (1985). Combined Use of Tricyclic Antidepressants and Neuroleptics in the Management of Terminally 111 Children: A Report on Three Cases. Journal of the American Academy of Child Psychiatry, 24(4), 487–489. https://doi.org/10.1016/S0002-7138(09)60569-0