Impaired endothelial function and insulin action in first-degree relatives of patients with type 2 diabetes mellitus

12Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

First-degree relatives (FDR) of patients with type 2 diabetes mellitus are at increased risk of developing type 2 diabetes mellitus. We studied if endothelial dysfunction of the resistance vessels is present and may coexist with metabolic insulin resistance in FDR. Male FDR (n = 13; 26 ± 1 years; body mass index, 25 ± 1 kg m2 [mean ± SEM]) and matched control subjects (CON) (n = 22; 25 ± 1 years; body mass index, 24 ± 1 kg m2) were studied by hyperinsulinemic (40 mU min-1{dot operator}m-2) isoglycemic clamp combined with brachial arterial and deep venous catheterization of the forearm. Forearm blood flow (FBF) was measured by venous occlusion plethysmography upon stimulation with systemic hyperinsulinemia (291 ± 11 pmol/L, pooled data from both groups) and upon intraarterial infusion of adenosine (ADN) and acetylcholine (ACH) ± hyperinsulinemia. Forearm blood flow response to ADN and ACH was less in FDR vs CON (P < .05); systemic hyperinsulinemia added to the FBF effect of ADN in CON (P < .05) but not in FDR. In addition, FDR demonstrated impaired FBF to hyperinsulinemia (2.1 ± 0.2 vs 4.0 ± 0.6 mL 100 mL-1 min-1) in FDR and CON, respectively (P < .05). Both M-value (5.0 ± 0.7 vs 7.0 ± 0.5 mg min-1 kg-1) and forearm glucose clearance (0.6 ± 0.1 vs 1.4 ± 0.4 mL 100 mL-1{dot operator}min-1) were diminished in FDR compared with CON (all P < .05). FDR demonstrated endothelial dysfunction of the resistance vessels in addition to impaired insulin-stimulated increase in bulk flow. Moreover, FDR demonstrated whole-body insulin resistance as well as decreased basal and insulin-stimulated forearm glucose uptake. It remains to be established whether FDR also demonstrate impaired insulin-stimulated microvascular function. © 2009 Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Sonne, M. P., Højbjerre, L., Alibegovic, A. A., Vaag, A., Stallknecht, B., & Dela, F. (2009). Impaired endothelial function and insulin action in first-degree relatives of patients with type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 58(1), 93–101. https://doi.org/10.1016/j.metabol.2008.08.011

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free