A bio. tools collection of online resources for GPCR research

Abstract

G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research. LINKED ARTICLES: This article is part of a themed issue Complexity of GPCR Modulation and Signaling (ERNST). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.14/issuetoc.