Synthesis and antibacterial activity of novel fluoroquinolone analogs

Abstract

Fluoroquinolone analogs were synthesized by reductive amination and screened for their antibacterial activities against E. coli K12 and S. aureus RN4220. Out of 18 compounds under the present study, 8 compounds were found most active against S. aureus RN4220 and E. coli K12, respectively, with MIC < 0.062 μg/mL, which sufficiently potent for possible clinical application. All synthesized compounds were characterized by various spectroscopic techniques viz. IR, 1 H and 13 C NMR, and mass spectrometry. Out of these, one compound (3) was also characterized by the single crystal X-ray analysis. In order to understand the molecular interactions of these compounds (5-22) with enzyme DNA gyrase, molecular docking of two compounds viz. compounds 9 and 11 was also performed and we found promising results.