Local infiltration of tramadol as an effective strategy to reduce post-operative pain: A systematic review protocol and meta-analysis

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Objective: The purpose of this review is to evaluate the use and effectiveness of the local administration of tramadol in reducing post-operative pain during surgical interventions. Methods: The PubMed, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) databases will be searched for this review. This systematic review will include studies evaluating the clinical efficacy of the local infiltration of tramadol, with no study design restrictions. Only studies that present clear descriptions of local tramadol administration are published in peer-reviewed journals in the English, Italian, Spanish, French, Portuguese or German language and are published in full will be taken into consideration. A meta-analysis will be performed when there is sufficient clinical homogeneity among the retrieved studies, and only randomized controlled studies and quasi-randomized controlled studies will be included. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used to assess the certainty in the evidence. If a quantitative analysis cannot be conducted, a qualitative description of the results of the retrieved studies will be provided. Results: A high-quality synthesis of the current evidence on the local administration of tramadol for managing post-surgical pain will be illustrated using subjective reports and objective measures of performance. The primary outcomes will include the magnitude of post-operative pain intensity improvement, with improvement being as defined by a reduction by at least 2 points in the visual analogue scale (VAS) score or numerical rating scale (NRS) score. The secondary outcomes will be the magnitude of reduction in tramadol rescue doses and in other analgesic drug doses. Conclusion: This protocol will present evidence on the efficacy of tramadol in relieving post-surgical pain. Systemic review registration: PROSPERO CRD42018087381




Passavanti, M. B., Piccinno, G., Alfieri, A., Di Franco, S., Sansone, P., Mangoni, G., … Fiore, M. (2020, July 13). Local infiltration of tramadol as an effective strategy to reduce post-operative pain: A systematic review protocol and meta-analysis. Systematic Reviews. BioMed Central. https://doi.org/10.1186/s13643-020-01419-1

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