Saponin and Sapogenol. L. On the Constituents of the Roots of Glycyrrhiza uralensis Fischer from Xinjiang, China. Chemical Structures of Licorice-Saponin L3 and Isoliquiritin Apioside

Abstract

From the air-dried roots of Glycyrrhiza uralensis Fischer collected in Xinjiang province, China (“Shinkyo-Kanzo” in Japanese), a new oleanene-type triterpene oligoglycoside named licorice-saponin L3 and a new chalcone oligoglycoside named isoliquiritin apioside were isolated together with glycyrrhizin, 18a-glycyrrhizin, apioglycyrrhizin, arabo-glycyrrhizin, licorice-saponins A3, E2, G2, and H2, and six known flavonoid glycosides. On the basis of chemical and physicochemical evidence, the structures of licorice-saponin L3 and isoliquiritin apioside were elucidated as 3β-[α-L-rhamnopyranosyl(l→2)-α-L-arabinopyranosyl(l→2)-β-D-glucuronopyranosyloxy]-22β-acetoxy-24-hydroxyolean-12- en-30-oic acid (1) and 4-O-[β-D-apiofuranosyl(l→2)-β-D-glucopyranosyl]isoliquiritigenin (6), respectively. © 1993, The Pharmaceutical Society of Japan. All rights reserved.