In this issue of Immunity, Schulz et al. (2009) use mathematical modeling to elucidate a signaling network controlling Ifng gene expression, thereby showing the importance of an Interleukin-12-dependent, Interferon-γ-independent second phase of inducing the transcription factor T-bet. © 2009 Elsevier Inc. All rights reserved.
Boothby, M. (2009, May 22). The Calculus of Integrating Differentiation: Timing Control of T-Bet. Immunity. https://doi.org/10.1016/j.immuni.2009.04.008