Carcinomas of thyroglossal duct cysts are rare. Most are papillary carcinomas; only about 5% are squamous cell carcinomas. Only one case of mixed papillary and squamous cell carcinoma of a thyroglossal duct cyst has been reported so far. The authors present a second case, that of a 38-year- old man who was first seen with a midline neck lump. It was diagnosed clinically as a thyroglossal duct cyst and was locally excised. Pathological examination showed both a concurrent papillary carcinoma and a squamous cell carcinoma. Treatment consisted of a near-total thyroidectomy, ablative radioactive iodine and adjuvant external radiation therapy. The authors review the literature and explain the rationale behind their choice of treatment.
Kwan, W. B., Liu, F. F., Banerjee, D., Rotstein, L. E., & Tsang, R. W. (1996). Concurrent papillary and squamous carcinoma in a thyroglossal duct cyst: A case report. Canadian Journal of Surgery, 39(4), 328–332. https://doi.org/10.1016/s0022-3468(97)90075-0