HSV-1 ICP27 suppresses NF-κB activity by stabilizing IκBα

0Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Nuclear factor κB (NF-κB) is associated with the transcriptional activation of genes encoding chemokines, adhesion molecules, cytokines, and anti-apoptotic proteins, which are key components in immune responses and viral infection. Many viruses modulate NF-κB through numerous viral gene products to allow productive infections and immune escape. Here we report that herpes simplex virus-1 infected cell protein 27 (HSV-1 ICP27), an immediate early protein of HSV-1, represses NF-κB activity through binding to inhibitor of κB (IκBα), blocking phosphorylation and ubiquitination of IκBα, and stabilizing IκBα. These data may explain how NF-κB activity is regulated by ICP27 to escape immune responses during the very early period of HSV-1 infection. Structured summary: MINT-6549405:IkappaBalpha (uniprotkb:P25963) physically interacts (MI:0218) with ICP27 (uniprotkb:Q9J0X9) by anti bait coimmunoprecipitation (MI:0006)MINT-6549385:IkappaBalpha (uniprotkb:P25963)physically interacts (MI:0218) with ICP27 (uniprotkb:Q9J0X9) by anti tag coimmunoprecipitation (MI:0007)MINT-6549372:IkappaBalpha (uniprotkb:P25963) physically interacts (MI:0218) with ICP27 (uniprotkb:Q9J0X9) by pull down (MI:0096). © 2008 Federation of European Biochemical Societies.

Author supplied keywords

Cite

CITATION STYLE

APA

Kim, J. C., Lee, S. Y., Kim, S. Y., Kim, J. K., Kim, H. J., Lee, H. M., … Ahn, J. K. (2008). HSV-1 ICP27 suppresses NF-κB activity by stabilizing IκBα. FEBS Letters, 582(16), 2371–2376. https://doi.org/10.1016/j.febslet.2008.05.044

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free