Treatment of chronic deep vein thrombosis using ultrasound accelerated catheter-directed thrombolysis

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Objective To evaluate the feasibility, efficacy and safety of ultrasound-accelerated catheter-directed thrombolysis (UACDT) in the delayed treatment of lower extremity deep venous thrombosis (DVT). Design Twelve patients with unilateral iliofemoral or femoropopliteal DVT (mean symptom duration 92 ± 44 days) were prospectively investigated. Method UACDT was performed using recombinant human tissue plasminogen activator delivered using the EKOS EkoSonic system. Stents were deployed if indicated by post-procedure venography. Follow-up comprised weekly duplex ultrasound for 1 month and monthly thereafter. Results Successful thrombolysis occurred in 11/12 limbs (92%; complete 6/12, partial 5/12) after a mean infusion time of 26 ± 7 hours. 2/12 patients required angioplasty and stent insertion. At a mean follow-up of 9 (6-15) months, 10/11 (91%) veins were patent whereas 1/11 re-occluded at 2 months (patient with protein-C deficiency). 2/11 limbs developed symptoms/signs of post-thrombotic syndrome and 3/11 had developed deep vein reflux (duplex ultrasound). 2/12 patients experienced peri-catheter bleeding but no major hemorrhage or symptomatic pulmonary embolism occurred. Conclusions This preliminary evidence suggests that UACDT may be a safe and effective option for the delayed treatment of lower limb DVT. © 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.




Dumantepe, M., Tarhan, I. A., & Ozler, A. (2013). Treatment of chronic deep vein thrombosis using ultrasound accelerated catheter-directed thrombolysis. European Journal of Vascular and Endovascular Surgery, 46(3), 366–371.

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