Treatment of chronic deep vein thrombosis using ultrasound accelerated catheter-directed thrombolysis

16Citations
Citations of this article
37Readers
Mendeley users who have this article in their library.

Abstract

Objective To evaluate the feasibility, efficacy and safety of ultrasound-accelerated catheter-directed thrombolysis (UACDT) in the delayed treatment of lower extremity deep venous thrombosis (DVT). Design Twelve patients with unilateral iliofemoral or femoropopliteal DVT (mean symptom duration 92 ± 44 days) were prospectively investigated. Method UACDT was performed using recombinant human tissue plasminogen activator delivered using the EKOS EkoSonic system. Stents were deployed if indicated by post-procedure venography. Follow-up comprised weekly duplex ultrasound for 1 month and monthly thereafter. Results Successful thrombolysis occurred in 11/12 limbs (92%; complete 6/12, partial 5/12) after a mean infusion time of 26 ± 7 hours. 2/12 patients required angioplasty and stent insertion. At a mean follow-up of 9 (6-15) months, 10/11 (91%) veins were patent whereas 1/11 re-occluded at 2 months (patient with protein-C deficiency). 2/11 limbs developed symptoms/signs of post-thrombotic syndrome and 3/11 had developed deep vein reflux (duplex ultrasound). 2/12 patients experienced peri-catheter bleeding but no major hemorrhage or symptomatic pulmonary embolism occurred. Conclusions This preliminary evidence suggests that UACDT may be a safe and effective option for the delayed treatment of lower limb DVT. © 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Cite

CITATION STYLE

APA

Dumantepe, M., Tarhan, I. A., & Ozler, A. (2013). Treatment of chronic deep vein thrombosis using ultrasound accelerated catheter-directed thrombolysis. European Journal of Vascular and Endovascular Surgery, 46(3), 366–371. https://doi.org/10.1016/j.ejvs.2013.05.019

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free