QuantiFERON-TB Gold IT analyses interferon-γ release from CD4+ T cells after stimulation with specific tuberculosis (TB) antigens. Its sensitivity is approximately 80% for active TB. A new test generation (QFTGplus) also analyses the response of CD8+ T cells. We investigated both test generations in a direct head-to-head comparison in a German pulmonary hospital. Sensitivity rates for active TB were identical, no matter whether diagnosis was bacteriologically confirmed or not.
Hoffmann, H., Avsar, K., Göres, R., Mavi, S. C., & Hofmann-Thiel, S. (2016). Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version QuantiFERON-TB Gold IT. Clinical Microbiology and Infection, 22(8), 701–703. https://doi.org/10.1016/j.cmi.2016.05.006