Effect of mangiferin on muscle GLUT4 protein content in TSOD (Tsumura, Suzuki, Obese, Diabetes) mouse, a new type 2 diabetic mice

Abstract

The effect of Mangiferin (MF) on muscle GLUT4 protein content was studied in TSOD (Tsumura, Suzuki, Obese, Diabetes) mice, a new animal model of type 2 diabetes with hyperinsulinemia. MF reduced the blood glucose of TSOD mice 7 h after oral administration, and also significantly lowered the serum insulin of TSOD mice under similar conditions. The muscle content of facilitative glucose transporter isoform 4 (GLUT4) protein content in the plasma membrane fraction of muscle significantly increased in the orally MF-treated mice when compared with that in the controls. These results suggest that the antidiabetic effect of MF is derived, at least in part, from the increase of GLUT4 protein content in the plasma membrane of the muscle.