Heterobimetallic complexes of platinum(II) with diferrocenylphenylphosphine and their in vitro activity against P388 leukaemia

Abstract

Four platinum(II) complexes of the general formula cis-[Pt{(Ferr)2PhP}(DMSO)X2], where X2 = Cl2, C2O4, O2(CO)2(C6H11)2 and O2(CO)2-CCH2CH2CH2, have been synthesized and characterized physicochemically and spectroscopically as the first heterobimetallic platinum(II) complexes with the ligand diferrocenylphenylphosphine (Ferr = ferrocenyl). These complexes were tested in vitro against leukaemia cell line P388 using the MTT assay. The results obtained were compared with those of cisplatin, carboplatin, oxaliplatin and 5-fluorouracil. Copyright © 1999 John Wiley & Sons, Ltd.