Hypoxia is a common feature for most malignant tumors, which was also closely related to the oxygen-dependent photodynamic therapy. Based on Förster resonance energy transfer (FRET), a smart nanoprobe (designated as H-Probe) was designed in this paper for hypoxia imaging and photodynamic tumor therapy. Due to the FRET process, H-Probe could respond to hypoxia with a significant fluorescence recovery. Moreover, abundant in vitro investigations demonstrated that the photosensitizer of PpIX in H-Probe could generate large amounts of singlet oxygen to kill cancer cells in the presence of oxygen and light with appropriate wavelength. Also, intravenously injected H-Probe with light irradiation achieved an effective tumor inhibition in vivo with a reduced side effect. This original strategy of integrating hypoxia imaging and tumor therapy in one nanoplatform would promote the development of theranostic nanoplatform for tumor precision therapy.
CITATION STYLE
Fan, J. H., Fan, G. L., Yuan, P., Deng, F. A., Liu, L. S., Zhou, X., … Li, S. Y. (2019). A Theranostic Nanoprobe for Hypoxia Imaging and Photodynamic Tumor Therapy. Frontiers in Chemistry, 7. https://doi.org/10.3389/fchem.2019.00868
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