Formulation and Evaluation of Flurbiprofen Aqueous Injection

Abstract

Objective: The objective of this research was to formulation and evaluation of flurbiprofen aqueous injection. Methods: The flurbiprofen aqueous injection was successfully developed by mixed hydrotrophy technique, using sodium benzoate, sodium acetate, and propylene glycol, glycerin, peg200, peg400, peg4000, peg6000, urea and ethanol as solvent in various proportions in combination. Further, the prepared aqueous injection were characterized for qualitative solubility, quantitative solubility, dilution study, effect of ph extractable volume test, viscosity, visual check, bet test, sterility test, particulate contamination, compatibility studies (FTIR) and stability studies. Results: The consequences of solvency studies are exhibited. It appears from the outcomes that the watery dissolvability of flurbiprofen was expanded more circumstances in hydrotropic mix specialists (PG25%+PEG10%+S5%), (SB5%+PEG 25%+S10%).1 In hydrotropic arrangement which additionally utilized for group assembling and testing reason all cluster demonstrates great soundness and manufactured products show stable results. Conclusion: The dissolvability assurance of flurbiprofen was completed in distilled water, hydrotropic arrangements containing diverse convergences of hydrotropic. It is possible to make further more studies to develop for industrial manufacturings.