Abstract
The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production.
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CITATION STYLE
Urata, S., Weyer, J., Storm, N., Miyazaki, Y., van Vuren, P. J., Paweska, J. T., & Yasuda, J. (2016). Analysis of Assembly and Budding of Lujo Virus. Journal of Virology, 90(6), 3257–3261. https://doi.org/10.1128/jvi.03198-15
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