Correlation between factor VII and PAI-1 genetic variants and recurrent miscarriage

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Abstract

Background: Polymorphisms which are presented below may be the cause of inherited thrombophilia and may result in pregnancy loss. The hypothesis is based on a number of cardiology studies which have confirmed the involvement of these polymorphisms in thrombotic incidents. Objectives: To evaluate the role of polymorphisms of factor VII gene (Arg353Gln, -122T > C) and PAI-1 gene (-675 4G/5G) in the etiology of recurrent miscarriage. Material and methods: The study group included 152 women with a positive history of = 2 consecutive pregnancy losses (114 and 38 women with 2 and ≥ 3 miscarriages, respectively), while 180 healthy women were recruited as controls. Genetic analysis was performed with the use of PCR/RFLP. Results: Lower frequency of Arg353/Gln353 was observed in women with 2 and ≥ 3 miscarriages as compared to controls (21.1% vs. 23.9% and 13.2% vs. 23.9%, respectively). The frequency of Gln353 was lower in women with ≥ 3 miscarriages as compared to controls (6.6% vs. 11.9%, p = ns). The frequency of -122TT was higher in women with ≥ 3 miscarriages as compared to controls (86.84% vs. 76.67%, p = ns), whereas -122TC was more frequent in controls (13.16% vs. 22.78% in controls, p = ns). The frequency of -122T was higher in patients with ≥ 3 abortions as compared to controls (93.42% vs. 88.06%, p = ns), and -122C was observed more frequently in controls (6.58% vs. 11.94% in controls, p = ns). There were no significant differences as far as the -675 4G/5G polymorphism was concerned. Conclusions: The obtained results suggest a possible protective role of Gln353 and -122C alleles in recurrent miscarriage.

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APA

Barlik, M., Seremak-Mrozikiewicz, A., Drews, K., Klejewski, A., Kurzawińska, G., Łowicki, Z., & Wolski, H. (2016). Correlation between factor VII and PAI-1 genetic variants and recurrent miscarriage. Ginekologia Polska, 87(7), 504–509. https://doi.org/10.5603/GP.2016.0034

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