To study the impact of starch on colonic function and metabolism, 12 healthy volunteers consumed a controlled diet rich in starch for two 4-wk periods. In one of the study periods they received the glucosidase inhibitor acarbose (BAY g 5421) and placebo in the other. Stool wet weight increased by 68%, stool dry weight by 57%, fecal water content by 73%, and the mean transit time by 30% on acarbose. Breath hydrogen was significantly higher on acarbose, indicating stimulated carbohydrate fermentation in the colon. Fecal bacterial mass (+78%), total stool nitrogen (+53%), bacterial nitrogen (+200%), and stool fat (+56%) were higher in the acarbose than in the control period. The stimulation of fermentation in the human large intestine may be important in colonic and possibly other diseases. © 1988, American Gastroenterological Association. All rights reserved.
Scheppach, W., Fabian, C., Ahrens, F., Spengler, M., & Kasper, H. (1988). Effect of Starch Malabsorption on Colonic Function and Metabolism in Humans. Gastroenterology, 95(6), 1549–1555. https://doi.org/10.1016/S0016-5085(88)80076-3