• Berbari J
  • Reynolds S
  • Heil-Ruess M
  • et al.
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OBJECTIVES: A systematic review of the literature was performed to gather the epidemiological evidence related to atopic dermatitis (AD) in a pediatric population. METHODS: OVID MEDLINE(registered trademark) was searched using terms related to AD, epidemiology, incidence/prevalence in a population <18 years old. Two researchers undertook the inclusion/exclusion process on the 466 citations that had been identified. A third person acted as an overall reviewer and adjudicator. RESULTS: The major finding was the International Study of Asthma and Allergies in Childhood (ISAAC) whichreported the prevalence ofAD in children6-7 years old from35 countries at two distinct time periods (around 1995 and 2002). A further 32 independent studies were identified for inclusion in this review. These studies reported on incidence (n=2), prevalence (n=25) or both (n=5) in Europe (n=23), Southeast Asia (n= 8) and Africa (n= 1). The number of study participants differed greatly (n=137 to n=317,926). According to ISAAC, the worldwide prevalence rate of AD increased by a rate of 36% from 12.9% in 1995 to 17.5% in 2002. Over that same time period, a 46% increase was reported for North America and Western Europe with the largest increase (95%) observed in Latin America. By 2002, many (n=9) countries had reached absolute prevalence rates > 30%. The high prevalence of AD as reported by ISAAC was confirmed in the remaining literature, especially in a population of young children and infants, with rates of up to 60%. The reported incidence rates for a similar population were as high as approximately 10%. CONCLUSIONS: AD is one of the most prevalent disease conditions in childhood, with an increasing trend in most parts of the world. (Author address: J. Berbari, Pharmldeas Research and Consulting, Ottawa, Canada) [EMBASE KEYWORDS:society, human, child, atopic dermatitis, systematic review, outcomes research, pharmacoeconomics, prevalence, population, childhood, allergy, asthma, epidemiology, Europe, Southeast Asia, Africa, North America, Western Europe, South and Central America, infant, incidence]




Berbari, J., Reynolds, S., Heil-Ruess, M., & Iskedjian, M. (2011). PSS4 SYSTEMATIC REVIEW OF THE EPIDEMIOLOGIC LITERATURE ON ATOPIC DERMATITIS IN CHILDREN. Value in Health, 14(3), A53–A54.

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