Value of integrated PET/CT in detection of hepatic metastatic deposits

Citations of this article
Mendeley users who have this article in their library.


Purpose The goal of this study was to assess the value of combined PET/CT using 18F-FDG in detection and characterization of hepatic metastatic lesions compared to isolated PET and CT in various malignancies. Patients and methods The study included 82 patients divided into six groups of primary malignancies to whom PET/CT scans were done. Detailed retrograde lesion based and patient based analyses were performed for 441 detected hepatic lesions in 82 patients to detect metastasis on PET, CT and PET/CT. A final diagnosis of metastasis was confirmed by biopsy or by further clinical and radiologic work-up. Results Regarding lesion based analysis, the PET/CT showed 98% sensitivity, 100% specificity, 100% PPV, 84% NPV and 98% accuracy compared with 98%, 98%, 99.7%, 84% and 98%, respectively, for PET, and 95%, 81%, 98%, 63% and 94%, respectively, for CT. In patient-based analysis, PET/CT and PET showed 99% sensitivity, 100% specificity, 100% PPV, 90% NPV and 99% accuracy compared with 100%, 56%, 95%, 100% and 95%, respectively for CT. The combined PET/CT has significantly improved the low CT sensitivity as well as both CT and PET specificities. Conclusion PET/CT provides accurate detection of hepatic metastasis and their metabolic nature which significantly affect further management.

Author supplied keywords




Ali, S. A., & Abd Elkhalek, Y. I. (2016). Value of integrated PET/CT in detection of hepatic metastatic deposits. Egyptian Journal of Radiology and Nuclear Medicine, 47(2), 459–465.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free