Bioactive constituents from roots of Salvia syriaca L.: Acetylcholinesterase inhibitory activity and molecular docking studies

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Abstract

Several Salvia species have been used to enhance memory in European traditional medicine. Accordingly, we aimed to evaluate the acetone extract of the roots of Salvia syriaca for anti-Alzheimer constituents. Structures of purified compounds were determined as ursolic acid, corosolic acid, β-sitosterol, urs-12-en-2α,3β-diol and daucosterol (1-5). β-sitosterol and daucosterol exhibited high acetylcholinesterase inhibitory activities (24.1 and 34.3 μg/mL, respectively). The experimental results were also confirmed by docking analysis.

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Bahadori, M. B., Dinparast, L., Valizadeh, H., Farimani, M. M., & Ebrahimi, S. N. (2016). Bioactive constituents from roots of Salvia syriaca L.: Acetylcholinesterase inhibitory activity and molecular docking studies. South African Journal of Botany, 106, 1–4. https://doi.org/10.1016/j.sajb.2015.12.003

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