Abstract
G-quadruplexes (G4s) are non-canonical DNA secondary structures. The identification of selective tools to probe individual G4s over the ∼700 000 found in the human genome is key to unravel the biological significance of specific G4s. We took inspiration from a crystal structure of the bovine DHX36 helicase bound to the G4 formed in the promoter region of the oncogene c-MYC to identify a short peptide that preferentially binds MYC G4 with nM affinity over a small panel of parallel and non-parallel G4s tested.
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CITATION STYLE
Minard, A., Morgan, D., Raguseo, F., Di Porzio, A., Liano, D., Jamieson, A. G., & Di Antonio, M. (2020). A short peptide that preferentially binds c-MYC G-quadruplex DNA. Chemical Communications, 56(63), 8940–8943. https://doi.org/10.1039/d0cc02954h
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