Ixora parviflora protects against UVB-induced photoaging by inhibiting the expression of MMPs, MAP kinases, and COX-2 and by promoting type i procollagen synthesis

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Abstract

Ixora parviflora with high polyphenol content exhibited antioxidant activity and reducing UVB-induced intracellular reactive oxygen species production. In this study, results of the photoaging screening experiments revealed that IPE at 1000g/mL reduced the activity of bacterial collagenase by 92.7 4.2 and reduced the activity of elastase by 32.6 1.4. Therefore, we investigated the mechanisms by which IPE exerts its anti-photoaging activity. IPE at 1g/mL led to an increase in type I procollagen expression and increased total collagen synthesis in fibroblasts at 5g/mL. We found that IPE inhibited MMP-1, MMP-3, and MMP-9 expression at doses of 1, 5, and 10g/mL, respectively, in fibroblasts exposed to UV irradiation (40mJ/cm 2). Gelatin zymography assay showed that IPE at 50g/mL inhibited MMP-9 secretion/activity in cultured fibroblasts after UVB exposure. In addition, IPE inhibited the phosphorylation of p38, ERK, and JNK induced by UVB. Furthermore, IPE inhibited the UVB-induced expression of Smad7. In addition, IPE at 1g/mL inhibited NO production and COX-2 expression in UV-exposed fibroblasts. These findings show that IPE exhibits anti-inflammatory and anti-photoaging activities, indicating that IPE could be a potential anti-aging agent. Copyright © 2012 Kuo-Ching Wen et al.

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Wen, K. C., Fan, P. C., Tsai, S. Y., Shih, I. C., & Chiang, H. M. (2012). Ixora parviflora protects against UVB-induced photoaging by inhibiting the expression of MMPs, MAP kinases, and COX-2 and by promoting type i procollagen synthesis. Evidence-Based Complementary and Alternative Medicine, 2012. https://doi.org/10.1155/2012/417346

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