Emi1 proteolysis: How SCFβ-Trcp1 helps to activate the anaphase-promoting complex

Abstract

Emi1 inhibits the anaphase-promoting complex (APC) during S and G2 phase. Two papers by Guardavaccaro et al. and Margottin-Goguet et al. in the June issue of Developmental Cell now show that Emi1 degradation in early mitosis is mediated by β-Trcp1, an adaptor protein that recruits proteins to the SCF ubiquitin ligase.