Influence of vitamin D status on the effect of statins on bone mineral density and bone turnover markers in postmenopausal women

Abstract

Objective: This study sought to assess whether the association between statin use and bone mineral density (BMD) and bone turnover markers is modulated by serum 25-hydroxyvitamin D (25OHD) levels in postmenopausal women. Copyright Design, Participants, and Settings: Approximately 1422 postmenopausal women were recruited from the Camargo Cohort after excluding those with any known medical disorder or drug that might affect bone metabolism. Participants were categorized into four groups: 25OHD levels of 20 ng/mL or less and not taking statins (group 1; n = 492); 25OHD levels greater than 20 ng/mL and on statins (group 2; n=143); 25OHD levels of 20 ng/mL or less and using statins (group 3; n=112); and2OHDlevels greater than 20 ng/mL and non-statin use (group 4; n=675). Multivariate analyses were performed to compare BMD and bone turnover markers between groups. Results: Women in group 2 had an adjusted femoral neck and total hip BMD higher than women in group 1 (P