In vitro antimicrobial and anti-inflammatory activity of Jordanian plant extracts: A potential target therapy for Acne vulgaris

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Abstract

Acne vulgaris is a chronic inflammatory disorder in which Propionibacterium acnes plays a crit. role in its development when it overgrows in the pilosebaceous unit. The present study was conducted to evaluate the antimicrobial and anti-inflammatory activity of fourteen Mediterranean plant exts. sep. and in combinations for the treatment of acne. The methanolic plant exts. were tested against P. acnes by detg. the min. inhibitory concn. (MIC). The exts. that showed high antimicrobial activity were studied for their anti-inflammatory effect. They were evaluated for their ability to suppress the pro-inflammatory cytokines IL-1β, IL-8, IL-12 and the TNF-α release from PBMCs and mTNF-α from mouse splenocytes using ELISA assay. Rosmarinus officinalis was found to exhibit the highest antimicrobial activity amongst all of the tested exts. (MIC 0.5 mg/mL) followed by Origanum syriacum (MIC 1 mg/mL) and Punica granatum (MIC 1.25 mg/mL). 100 And 50 μg/mL of Chrysanthemum coronarium, Origanum syriacum or Inula viscosa exts. showed the most effective inhibition for the cytokine release. Six exts. had shown both anti-microbial and anti-inflammatory activities with apparent dose-dependent responses making them potential agents for the treatment of acne. Two mixts. prepd. from the plants with the highest antimicrobial activity had shown synergistic anti-microbial and anti-inflammatory effect. [on SciFinder(R)]

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APA

Amro, I. (2013). In vitro antimicrobial and anti-inflammatory activity of Jordanian plant extracts: A potential target therapy for Acne vulgaris. African Journal of Pharmacy and Pharmacology, 7(29), 2087–2099. https://doi.org/10.5897/ajpp2013.3497

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