Incorporate gene signature profiling into routine molecular testing

3Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

The success of gene and gene expression profiling, such as the Onco. type DX® test for breast cancer patients, demonstrates that as technology becomes more sophisticated molecular diagnostics will continue to play a more important role in disease management in the future. Such promises have been and continue to be enabled by advances in real-time PCR, microarray detection platforms and next generation sequencing technologies. Practical adoption of new technologies into routine clinical care, however, has not always been a smooth ride. Challenges lie on several fronts: establishment of clinical validity in large scale patient population, mechanisms of incorporating molecular tests into standard care, and keeping up with the pace of ever changing technologies in regulated clinical laboratories, just to name a few. This review's goals are to educate, to stimulate discussion and to provoke efforts to build consensus, share resources, and establish standards in order to realize the promises of genomic technologies for routine patient care. © 2013 Elsevier B.V.

Cite

CITATION STYLE

APA

Chen, N. (2013). Incorporate gene signature profiling into routine molecular testing. Applied and Translational Genomics. Elsevier B.V. https://doi.org/10.1016/j.atg.2013.03.002

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free