An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity

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Abstract

The disordered SIRT1 N-terminal region contains an insulin-responsive sensor (IRS), comprising an acidic cluster (AC) and a 3-helix bundle (3HB), controlling enzyme activity. Insulin triggers DBC1 and PACS-2 binding to the IRS. DBC1 removes the protective shield that hides the IRS, enabling PACS-2 to bind the acidic cluster and the 3-helix bundle, inhibiting SIRT1.

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APA

Krzysiak, T. C., Thomas, L., Choi, Y. J., Auclair, S., Qian, Y., Luan, S., … Thomas, G. (2018). An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity. Molecular Cell, 72(6), 985-998.e7. https://doi.org/10.1016/j.molcel.2018.10.007

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