The objective of the work is physicochemical characterization of meloxicam (ME)-cyclodextrin (CD) binary systems both in solution and solid states and to improve the dissolution properties of meloxicam via complexation with α-, β- and γ-cyclodextrins. Detection of inclusion complexation was done in solution state by means of phase solubility analysis, mass spectrometry and 1H nuclear magnetic resonance (NMR) studies, and in solid state using differential scanning calorimetry (DSC), powder X-ray diffractometry, and in vitro dissolution studies. Phase solubility, mass spectrometry and 1H NMR studies in solution state revealed 1:1M complexation of meloxicam with all CDs. A true inclusion of ME with γ-CD at 1:1 and 1:2M in solid state was confirmed by DSC, powder XRD and scanning electron microscopy (SEM) studies. Dissolution properties of ME-CDs binary systems were superior when compared to pure ME. © 2004 Elsevier B.V. All rights reserved.
Naidu, N. B., Chowdary, K. P. R., Murthy, K. V. R., Satyanarayana, V., Hayman, A. R., & Becket, G. (2004). Physicochemical characterization and dissolution properties of meloxicam-cyclodextrin binary systems. Journal of Pharmaceutical and Biomedical Analysis, 35(1), 75–86. https://doi.org/10.1016/j.jpba.2004.01.003