Inhibitors of the heat shock response: Biology and pharmacology

Citations of this article
Mendeley users who have this article in their library.


A number of human diseases can be linked to aberrations in protein folding which cause an imbalance in protein homeostasis. Molecular chaperones, including heat shock proteins, act to assist protein folding, stability and activity in the cell. Attention has begun to focus on modulating the expression and/or activity of this group of proteins for the treatment of a wide variety of human diseases. This review will describe the progress made to date in developing pharmacological modulators of the heat shock response, including both agents which affect the entire heat shock response and those that specifically target the HSP70 and HSP90 chaperone families. © 2007 Federation of European Biochemical Societies.




Powers, M. V., & Workman, P. (2007, July 31). Inhibitors of the heat shock response: Biology and pharmacology. FEBS Letters.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free