Theory, Practical Application and Future Expectation of Percutaneous Absorption

Abstract

In order to fur ther develop topical dosage preparation and transdermal drug deliver y systems (TDDS) as a convenient DDS, it is necessar y to fully understand the skin structure and the per-cutaneous absorption of drugs. Here, the author explained skin penetration pathway of drugs and ki-netics aspect for the percutaneous absorption of drugs as well as skin concentration profiles, which are impor tant especially for evaluation of topical dosage preparation. In addition, the author explained about the use of skin-penetration enhancers and physical means to increase the skin permeation of drugs, which are impor tant in practical application. Great progress of AI (ar tificial intelligence) and IoT (internet of things) may derive completely new types of TDDS in the near future. That is why it is time to look back on the past for the sake of the future.