Influence of the use of psychotropic drugs on the increase of Escherichia coli resistance

Abstract

Introduction: Escherichia coli is one of the most investigated bacteria due to the diversity of impacts on human health; it can sometimes form new resistant strains through conjugation processes, becoming a real public health problem. Objective: to evaluate the relationship between prolonged use of psychotropic drugs and increased antimicrobial resistance in Escherichia coli strains. Methods: a comprehensive literature review was conducted using different databases of scientific importance; including 35 theses, research articles and reviews published in Spanish and English, from 2019 to 2023. Results: studies of patients under psychotropic treatment with tricyclic antidepressants and selective serotonin reuptake inhibitors for more than 3 months were analyzed; proving the appearance of dysbiosis in the intestinal microbiota. Conclusion: the appearance of dysbiosis in the intestinal microbiota of patients under treatment with psychotropic drugs such as tricyclic antidepressants and selective serotonin reuptake inhibitors, causes a reduction in beneficial bacteria and favors the necessary environment for an increase in pathogenic gram-negative bacteria with resistant mutated strains, specifically Escherichia coli.