Abstract
The microbial transformation of a steroidal alkaloid, dictyophlebine (1) with Rhizopus stolonifer (ATCC 10404) afforded three oxidized metabolites 2-4. Compound 2 was found to be a new product. These metabolites were structurally characterized on the basis of modern spectroscopic techniques. Their inhibitory activity towards acetyl- and butyrylcholinesterase has been evaluated and the new product 2 has been found to be more potent than the parent compound and other metabolites. © 2007 Pharmaceutical Society of Japan.
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Devkota, K. P., Choudhary, M. I., Nawaz, S. A., Lannang, A. M., Lenta, B. N., Fokou, P. A., & Sewald, N. (2007). Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer. Chemical and Pharmaceutical Bulletin, 55(4), 682–684. https://doi.org/10.1248/cpb.55.682
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