L'AMPK, régulateur de l'énergie et des fonctions des spermatozoïdes

Abstract

The 5'-AMP-activated protein kinase, AMPK, is a key protein kinase in the metabolism of the cell that regulates many metabolic pathways. The involvement of cell metabolism in sperm ability to fertilize is well established, but only a few studies have focused on the role of AMPK in the control of male fertility. This article summarizes the known role of AMPK in this area. AMPK is involved in the regulation of sperm quality by its action on the proliferation of Sertoli cells. AMPK also directly controls the quality of sperm by its involvement in the regulation of motility and acrosome reaction. It is also involved in the management of lipid peroxidation and gametes antioxidant enzymes. Thus, AMPK appears as a key signaling protein for sperm and male fertility control.