LINE retrotransposons actively shape mammalian genomes. Denli et al. reveal a new open reading frame, ORF0, on the antisense strand of human LINE-1 encoding a small regulatory protein. This finding may represent the birth of an emerging retrotransposon gene that can adopt various fates, as it can be fused to adjacent host sequences.
Boeke, J. D., & Fenyo, D. (2015, October 22). Much Ado about Zero. Cell. Cell Press. https://doi.org/10.1016/j.cell.2015.10.033