Renoprotective and hepatoprotective effects of hippocratea excelsa on metabolic syndrome in fructose-fed rats

Abstract

The metabolic syndrome is associated with the development of chronic kidney disease and liver damage. The aim of this research was to determine the effect of the ethanol bark extract of Hippocratea excelsa (HE) on high fructose consumption-induced adverse effects in the kidney and liver of rats. Rats with 20% fructose feeding for 12 weeks showed arterial hypertension, obesity, dyslipidaemia and developed oxidative stress, proteinuria, the activities of antioxidant enzymes in the renal cortex and liver were decreased, TGF-β1 increased, and kidney and liver damage were observed. After the treatment for 6 weeks with HE (30 and 100 mg/kg bw) renoprotective and hepatoprotective effects in high fructose induced metabolic syndrome in rats, were demonstrated.