INTRODUCTION AND OBJECTIVES: Activation of renal sympathetic nerves is the key to pathogenesis of essential hypertension. We aimed to assess effectiveness and safety of laparoscopic renal denervation for reduction of blood pressure in patients with treatmentresistant hypertension. METHODS: 7 pt were identified with treatment resistant hypertension having a baseline systolic blood pressure of 160 mm Hg, despite taking three or more antihypertensive drugs. They underwent laparoscopic renal denervation of both kidneys, with subsequent followup of 1 year. Primary endpoints were office blood pressure at 1, 3, 6, 9, and 12 months after the procedure. RESULTS: The baseline mean office blood pressure were 177/ 101 mm Hg and they were on mean 5(4-10) antihypertensive medications. Office blood pressures after procedure for four patients were reduced by -60/-30, -20/-10, +05/+05, +10/+5, and +15/+5 mmHg and other three patients -60/-30, +20/+10, +30/+11, +35/+11, and +30/+10 mm Hg at 1, 3, 6, 9, and 12 months, respectively. No procedure-related complication or renal function impairment or deterioration was recorded. CONCLUSIONS: Laparoscopic renal denervation had moderate effect on four patients causing sustained blood-pressure reduction, but other three patients had no effect on blood pressure at one year follow up, even though there was an initial drop in blood pressure in all patients. Nevertheless prospective randomized controlled trials will have to confirm the therapeutic effects and further implications of this new therapeutic modality.
Panackal, A., & Sinha, S. (2014). PD13-04 LAPAROSCOPIC RENAL DENERVATION IN PATIENTS WITH TREATMENT-RESISTANT HYPERTENSION. Journal of Urology, 191(4S). https://doi.org/10.1016/j.juro.2014.02.989