NLRP12 is an innate immune receptor whose regulation of NF-κB signaling in myeloid cells is critical in preventing multiple auto-inflammatory diseases. In this issue of Immunity, Lukens etal. (2015) show that a similar NLRP12-mediated mechanism is functionally important in Tcells.
Thaiss, C. A., & Elinav, E. (2015, April 21). NF-κB Regulation by NLRs: T Cells Join the Club. Immunity. Cell Press. https://doi.org/10.1016/j.immuni.2015.03.010